Sequence-dependent bending propensity of DNA as revealed by DNase I: parameters for trinucleotides

EMBO J. 1995 Apr 18;14(8):1812-8.

Abstract

Structural parameters characterizing the bending propensity of trinucleotides were deduced from DNase I digestion data using simple probabilistic models. In contrast to dinucleotide-based models of DNA bending and/or bendability, the trinucleotide parameters are in good agreement with X-ray crystallographic data on bent DNA. This improvement may be due to the fact that the trinucleotide model incorporates more sequence context information than do dinucleotide-based descriptions.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Crystallography, X-Ray
  • DNA / chemistry*
  • DNA / metabolism
  • Deoxyribonuclease I / metabolism*
  • Evaluation Studies as Topic
  • Models, Chemical
  • Molecular Sequence Data
  • Nucleic Acid Conformation*
  • Oligodeoxyribonucleotides / chemistry*

Substances

  • Oligodeoxyribonucleotides
  • DNA
  • Deoxyribonuclease I