Association of Glu 27 beta 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects

Lancet. 1995 May 13;345(8959):1213-4. doi: 10.1016/s0140-6736(95)91994-5.


Cells expressing the Glu 27 beta 2-adrenoceptor polymorphism show attenuated down-regulation of the receptor after long-term exposure to agonist. We studied beta 2-adrenoceptor genotype for the Gln/Glu 27 polymorphism and airway reactivity in 65 patients with mild to moderate asthma. Glu 27 homozygotes had a four-fold higher geometric mean methacholine PD20 (provocative dose) than individuals who were homozygous for the wild-type (Gln 27) form of the receptor; heterozygotes had an intermediate value (3.23, 0.86, 1.96 mumol, respectively). These data suggest that beta 2-adrenoceptor genotype is important in the establishment of the asthmatic phenotype.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Asthma / genetics*
  • Asthma / physiopathology
  • Base Sequence
  • Bronchial Hyperreactivity / diagnosis
  • Bronchial Hyperreactivity / genetics*
  • Genotype
  • Humans
  • Methacholine Chloride
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Polymorphism, Genetic
  • Receptors, Adrenergic, beta-2 / genetics*


  • Receptors, Adrenergic, beta-2
  • Methacholine Chloride