The thymosin beta 4 gene is strongly activated in neural tissues during early postimplantation mouse development

Neurosci Lett. 1995 Jan 16;184(1):63-6. doi: 10.1016/0304-3940(94)11169-j.

Abstract

We studied the temporal and spatial distribution of the mRNA encoding for thymosin beta 4 (T beta 4), a small acidic actin-sequestering peptide, during the early postimplantation mouse development. Analysis of total embryo RNA demonstrated a strong activation of T beta 4 gene after gastrulation and coincident with neurulation. In situ hybridization showed that T beta 4 mRNA was strongly expressed in the central nervous system and peripheral ganglia, paralleling the gradient of neuronal differentiation. An intense signal was also observed in intraventricular macrophages and blood vessels. The role of T beta 4 in mammalian neuroembryogenesis is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Differentiation
  • Embryonic and Fetal Development
  • Gene Expression Regulation, Developmental
  • In Situ Hybridization
  • Mice
  • Neurons / physiology*
  • Thalamus / embryology*
  • Thalamus / physiology
  • Thymosin / genetics*

Substances

  • Thymosin