Effect of the low molecular weight heparin/non steroidal anti-inflammatory drugs association on an experimental thrombosis induced by laser

Thromb Res. 1995 Feb 15;77(4):311-9. doi: 10.1016/0049-3848(95)93834-m.

Abstract

LMWH (Fraxiparine), and NSAIDs (Aspirin, Feldene, Indocid and Profenid) injected together in doses, 1 mg/kg (Aspirin was used at 100 mg/kg), subcutaneously into rats 30 minutes before the thrombosis induction by LASER beams, increased the number of LASER beams required to induce platelet thrombus formation, decreased the number of emboli and reduced the duration of embolization, compared with control (p < or = 0.05). Of all the studied NSAIDs being injected either with LMWH or separately 30 minutes before the thrombosis stimulation by LASER only Aspirin appeared to potentiate the antithrombotic effect of Fraxiparine. Neither LMWH nor NSAIDs (except for Aspirin) at the dosages used modified aggregatory parameters compared with control. But it was observed the inhibition of platelet aggregation by the associations of Fraxiparine with Aspirin, Feldene or Profenid, tested in the whole blood 90 minutes after the drug injections.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Aspirin / administration & dosage
  • Drug Therapy, Combination
  • Indomethacin / administration & dosage
  • Injections, Subcutaneous
  • Ketoprofen / administration & dosage
  • Lasers / adverse effects
  • Male
  • Nadroparin / therapeutic use*
  • Piroxicam / administration & dosage
  • Platelet Aggregation / drug effects
  • Rats
  • Rats, Wistar
  • Thrombolytic Therapy*
  • Thrombosis / drug therapy*
  • Thrombosis / etiology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Nadroparin
  • Piroxicam
  • Ketoprofen
  • Aspirin
  • Indomethacin