Gene amplifications in advanced-stage human prostate cancer

Urol Res. 1995;22(6):343-7. doi: 10.1007/BF00296872.

Abstract

Gene amplification is a model of proto-oncogene alterations occasionally observed in human tumors. This amplification can, in some cases, have prognostic value (N-myc in neuroblastoma, c-erbB2 and int-2 in breast cancer, etc.). Amplifications of the proto-oncogenes c-myc, c-erbB2 and int-2 have not yet been report in prostate adenocarcinoma, which, like breast cancer, is hormone dependent. We sought amplifications of these three proto-oncogenes by means of Southern blotting in 15 human prostate adenocarcinoma specimens, most of which were advanced (7 stage C and 6 stage D1 or D2). We confirmed the lack of c-myc and c-erbB2 amplification, regardless of the stage, in contrast to the case of breast cancer. Int-2 amplification was observed in one advanced tumor with bone metastases, out of a total of six stage D tumors. The precise frequency of int-2 amplification and its role in prostate carcinogenesis remain to be determined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / genetics*
  • Adenocarcinoma / pathology*
  • Aged
  • Fibroblast Growth Factor 3
  • Fibroblast Growth Factors / genetics
  • Gene Amplification*
  • Genes, erbB-2
  • Genes, myc
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Oncogenes
  • Prostatic Neoplasms / genetics*
  • Prostatic Neoplasms / pathology*
  • Proto-Oncogene Proteins / genetics

Substances

  • FGF3 protein, human
  • Fibroblast Growth Factor 3
  • Proto-Oncogene Proteins
  • Fibroblast Growth Factors