Benign hepatic tumors: focal nodular hyperplasia and hepatocellular adenoma

World J Surg. Jan-Feb 1995;19(1):13-8. doi: 10.1007/BF00316973.


Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HA) are uncommon benign hepatic tumors that continue to pose diagnostic and therapeutic challenges. An update of a recent Mayo Clinic experience is presented to highlight the management of patients harboring these neoplasms. A marked female predominance was seen. Incidental diagnosis was more prevalent with FNH, whereas symptomatic presentation was typical of HA. The frequency of oral contraceptive steroid use was similar regardless of tumor histology. Preoperative diagnosis remains difficult. Scintigraphy proved most specific, and ultrasonography and computed tomography were equally sensitive. Resection was employed in most patients. There was no mortality and minimal morbidity. Selective observation of FNH was uneventful, but resolution of HA after abstinence of oral contraceptive steroids was uncommon. These findings and data from the literature support selective management of benign liver tumors.

Publication types

  • Review

MeSH terms

  • Adenoma, Liver Cell / chemically induced
  • Adenoma, Liver Cell / pathology
  • Adenoma, Liver Cell / surgery*
  • Adult
  • Contraceptives, Oral, Hormonal / administration & dosage
  • Contraceptives, Oral, Hormonal / adverse effects
  • Female
  • Hepatectomy
  • Humans
  • Hyperplasia / surgery
  • Liver / drug effects
  • Liver / pathology*
  • Liver Neoplasms / chemically induced
  • Liver Neoplasms / pathology
  • Liver Neoplasms / surgery*
  • Male
  • Middle Aged


  • Contraceptives, Oral, Hormonal