Brain metastases--comparison of gadodiamide injection-enhanced MR imaging at standard and high dose, contrast-enhanced CT and non-contrast-enhanced MR imaging

Acta Radiol. 1995 May;36(3):300-6.


The aim was to compare the abilities of contrast-enhanced CT, non-contrast-enhanced MR imaging and contrast-enhanced MR imaging using standard (0.1 mmol/kg b.w.) and high (0.3 mmol/kg b.w.) doses of Gadodiamide injection to detect brain metastases (i.e. blood-brain barrier damage). Sixteen patients with at least 2 metastases found by CT were evaluated by MR imaging using non-contrast-enhanced spin-echo, T1-weighted, T2-weighted sequences, and contrast-enhanced spin-echo T1-weighted sequences at 2 dose levels. Gadodiamide injection was first given at the dose of 0.1 mmol/kg b.w. After imaging, another 0.2 mmol/kg b.w. was given, yielding a cumulative dose of 0.3 mmol/kg b.w. No contrast media-related adverse events were recorded. The images were evaluated openly by one and blindly by 2 investigators and the number of metastases, size, delineation (open study) and diagnostic certainty (blind study) of each individual metastasis noted. High-dose MR imaging showed significantly more and smaller metastases than any other examination, and gave a higher diagnostic certainty. All high-dose images were superior to those with the standard dose MR imaging when compared blindly in pairs. We conclude that spin-echo MR imaging with a high dose of Gadodiamide injection is an efficient way to improve the detection of brain metastases, in particular of small ones.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood-Brain Barrier
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / diagnostic imaging
  • Brain Neoplasms / secondary*
  • Contrast Media / administration & dosage*
  • Contrast Media / adverse effects
  • Female
  • Gadolinium DTPA*
  • Gadolinium* / administration & dosage
  • Gadolinium* / adverse effects
  • Humans
  • Image Enhancement*
  • Image Processing, Computer-Assisted
  • Injections, Intravenous
  • Magnetic Resonance Imaging* / methods
  • Male
  • Observer Variation
  • Organometallic Compounds* / administration & dosage
  • Organometallic Compounds* / adverse effects
  • Pain / etiology
  • Pentetic Acid / administration & dosage
  • Pentetic Acid / adverse effects
  • Pentetic Acid / analogs & derivatives*
  • Radiographic Image Enhancement*
  • Single-Blind Method
  • Tomography, X-Ray Computed*


  • Contrast Media
  • Organometallic Compounds
  • Pentetic Acid
  • gadodiamide
  • Gadolinium
  • Gadolinium DTPA