Hyperbaric oxygen, oxygen-ozone therapy, and rheologic parameters of blood in patients with peripheral occlusive arterial disease

Undersea Hyperb Med. 1995 Mar;22(1):17-22.


For many years, clinical practice has consolidated the use of both hyperbaric oxygen and oxygen-ozone therapy in the treatment of peripheral occlusive arterial disease (POAD). We investigated the influence of these treatments on hemorrheologic parameters that play an important role in the pathogenesis and the clinical course of arteriosclerosis. Two groups of 15 patients suffering from POAD, assigned at random either to a cycle of HBO therapy or O2-O3 therapy, were evaluated for blood viscosity, erythrocyte filterability, hematocrit value, fibrinogen concentration, and thrombin time. The O2-O3 therapy caused a significant increase of erythrocyte filterability and a significant decrease of blood viscosity. By contrast, HBO therapy did not produce any significant change. The increase of lipid peri-oxidation, proved by raised malonyldialdehyde plasma levels, seems a likely mechanism involved in the hemorrheologic effects of O2-O3 therapy.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Arterial Occlusive Diseases / blood
  • Arterial Occlusive Diseases / physiopathology
  • Arterial Occlusive Diseases / therapy*
  • Blood Transfusion, Autologous
  • Female
  • Humans
  • Hyperbaric Oxygenation*
  • Male
  • Middle Aged
  • Oxygen / therapeutic use*
  • Ozone / therapeutic use*
  • Peripheral Vascular Diseases / blood
  • Peripheral Vascular Diseases / physiopathology
  • Peripheral Vascular Diseases / therapy*


  • Ozone
  • Oxygen