A critical analysis of the HIV-T4-cell-AIDS hypothesis

Genetica. 1995;95(1-3):5-24. doi: 10.1007/BF01434999.


The data generally accepted as proving the HIV theory of AIDS, HIV cytopathy, destruction of T4 lymphocytes, and the relationship between T4 cells, HIV and the acquired immune deficiency clinical syndrome are critically evaluated. It is concluded these data do not prove that HIV preferentially destroys T4 cells or has any cytopathic effects, nor do they demonstrate that T4 cells are preferentially destroyed in AIDS patients, or that T4 cell destruction and HIV are either necessary or sufficient prerequisites for the development of the clinical syndrome.

Publication types

  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / etiology*
  • Acquired Immunodeficiency Syndrome / immunology
  • Acquired Immunodeficiency Syndrome / virology
  • Apoptosis
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / pathology
  • Cytopathogenic Effect, Viral
  • HIV / isolation & purification
  • HIV / pathogenicity*
  • Humans
  • Immune Tolerance
  • Male
  • Models, Biological