Role of adjuvants in turning autoimmunity into autoimmune disease

Scand J Rheumatol Suppl. 1995;101:179-81. doi: 10.3109/03009749509100923.

Abstract

Autoreactive B- as well as T-lymphocytes are often integral parts of the normal immune system and are not per se pathogenic. Also activation of these autoreactive lymphocytes may in many cases occur without ensuing pathology. In the current paper is discussed two situations whereby unspecific inflammatory stimuli in the form of immunological adjuvants may either by themselves cause arthritis, or may change a non-pathogenetic to a destructive and chronic inflammatory disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adjuvants, Immunologic / physiology*
  • Animals
  • Arthritis / chemically induced
  • Arthritis, Experimental / physiopathology
  • Arthritis, Experimental / prevention & control
  • Autoimmune Diseases / etiology*
  • Autoimmunity / physiology
  • Collagen
  • Humans
  • Immunization

Substances

  • Adjuvants, Immunologic
  • Collagen