Visceral leishmaniasis in Somalia: prevalence of leishmanin-positive and seropositive inhabitants in an endemic area

Trans R Soc Trop Med Hyg. Jan-Feb 1995;89(1):21-4. doi: 10.1016/0035-9203(95)90640-1.

Abstract

In an endemic area of Somalia both humoral and cell mediated immunity against Leishmania donovani was demonstrated in 246 inhabitants. In a study of 14 patients with active visceral leishmaniasis, we found that antibodies appear early in infection and that they are then demonstrable for a limited period only. Leishmanin positivity develops later and persists longer, but does not seem to be lifelong. The majority of the immunoreactive individuals were either sero- or leishmanin positive. This finding is in accord with the result obtained in recent experimental studies indicating a regulatory effect exerted on humoral and cell mediated immunity by different T lymphocyte subsets.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Distribution
  • Aged
  • Animals
  • Antigens, Protozoan / analysis
  • Child
  • Child, Preschool
  • Humans
  • Infant
  • Infant, Newborn
  • Leishmania donovani
  • Leishmaniasis, Visceral / epidemiology*
  • Middle Aged
  • Prevalence
  • Somalia / epidemiology

Substances

  • Antigens, Protozoan
  • leishmanin