Glycine metabolism in anaerobes

Antonie Van Leeuwenhoek. 1994;66(1-3):223-37. doi: 10.1007/BF00871641.

Abstract

Some strict anaerobic bacteria catalyze with glycine as substrate an internal Stickland reaction by which glycine serves as electron donor being oxidized by glycine-cleavage system or as electron acceptor being reduced by glycine reductase. In both cases, energy is conserved by substrate level phosphorylation. Except for the different substrate-activating proteins PB, reduction of sarcosine or betaine to acetyl phosphate involves in Eubacterium acidaminophilum the same set of proteins as observed for glycine, e.g. a unique thioredoxin system as electron donor and an acetyl phosphate-forming protein PC interacting with the intermediarily formed Secarboxymethylselenoether bound to protein PA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Oxidoreductases / genetics
  • Amino Acid Oxidoreductases / metabolism
  • Anaerobiosis
  • Bacteria, Anaerobic / metabolism*
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • Clostridium / metabolism
  • Eubacterium / metabolism
  • Glycine / metabolism*
  • Glycine Dehydrogenase (Decarboxylating)
  • Multienzyme Complexes / genetics
  • Multienzyme Complexes / metabolism
  • Oxidation-Reduction
  • Oxidoreductases / metabolism
  • Proteins / metabolism
  • Selenoproteins
  • Thioredoxins / metabolism
  • Transferases / genetics
  • Transferases / metabolism

Substances

  • Carrier Proteins
  • Multienzyme Complexes
  • Proteins
  • Selenoproteins
  • glycine cleavage system
  • Thioredoxins
  • Oxidoreductases
  • Amino Acid Oxidoreductases
  • Glycine Dehydrogenase (Decarboxylating)
  • Transferases
  • Glycine