Effect of mitomycin C and fluorouracil-supplemented trabeculectomies on the anterior segment

Arch Ophthalmol. 1995 May;113(5):578-80. doi: 10.1001/archopht.1995.01100050044028.


Objectives: To determine whether there is increased risk to the corneal endothelium when mitomycin C is used in trabeculectomy surgery instead of fluorouracil, and whether these agents play a role in accelerating cataract formation.

Design, settings, and participants: We analyzed the corneal endothelium and the lens preoperatively and postoperatively in 30 eyes of 21 patients who underwent either a fluorouracil- or mitomycin C-supplemented trabeculectomy.

Results: No significant differences were found between these two groups in the rate of cataract progression, magnitude of endothelial cell loss, or appearance of endothelial cell morphologic characteristics. Endothelial cell loss accounted for approximately 7% to 8% of the preoperative counts in both groups. In addition, four (27%) of 15 eyes in each group showed evidence of cataract progression as graded by the Lens Opacities Classification System II.

Conclusion: Fluorouracil- and mitomycin C-supplemented trabeculectomies cause similar changes in the lens and corneal endothelium.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Anterior Eye Segment / cytology
  • Anterior Eye Segment / drug effects*
  • Cataract / chemically induced
  • Cell Count
  • Chemotherapy, Adjuvant
  • Female
  • Fluorouracil / adverse effects
  • Fluorouracil / therapeutic use*
  • Glaucoma / drug therapy
  • Glaucoma / surgery*
  • Humans
  • Male
  • Mitomycin / adverse effects
  • Mitomycin / therapeutic use*
  • Prospective Studies
  • Risk Factors
  • Trabeculectomy / methods*


  • Mitomycin
  • Fluorouracil