E-cadherin as a tumor (invasion) suppressor gene

Bioessays. 1995 Feb;17(2):97-9. doi: 10.1002/bies.950170203.


Diffuse-type gastric carcinomas show diminished cell-cell adhesion. A recent paper reports that 50% of these carcinomas contain mutations in the E-cadherin gene, resulting in the destruction of the calcium-binding sites of E-cadherin, and providing strong in vivo evidence that alterations in E-cadherin play a major role in the development of this particular type of cancer and the short survival of the patients.

Publication types

  • Review

MeSH terms

  • Adenomatous Polyposis Coli Protein
  • Antigens, CD
  • Cadherins / genetics*
  • Cell Adhesion Molecules / genetics
  • Cytoskeletal Proteins / genetics
  • Genes, Tumor Suppressor*
  • Humans
  • Mutation
  • Stomach Neoplasms / genetics*


  • Adenomatous Polyposis Coli Protein
  • Antigens, CD
  • CDH2 protein, human
  • Cadherins
  • Cell Adhesion Molecules
  • Cytoskeletal Proteins