Histones, HMG, HU, IHF: Même combat

Biochimie. 1994;76(10-11):901-8. doi: 10.1016/0300-9084(94)90014-0.


In this review article we present a compilation of the proteins homologous to Escherichia coli HU: the HU-like family. Two of these, HU and IHF from E coli have been extensively characterized genetically and biochemically. Due to their DNA binding activities, these proteins confer a condensed shape to the chromosome and regulate the transcription of selected sets of its genes. The parallel between the dual function of the HU-like proteins and the roles described for eukaryotic histone and HMG proteins is striking, especially in the view that they are evolutionary unrelated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Bacterial Proteins / chemistry
  • DNA-Binding Proteins / chemistry*
  • High Mobility Group Proteins / chemistry
  • Histones / chemistry*
  • Integration Host Factors
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid
  • Transcription Factors / chemistry


  • Bacterial Proteins
  • DNA-Binding Proteins
  • High Mobility Group Proteins
  • Histones
  • Integration Host Factors
  • Transcription Factors
  • histone-like protein HU, bacteria

Associated data

  • GENBANK/L35044
  • GENBANK/S00015
  • GENBANK/S35616
  • GENBANK/S37140
  • GENBANK/S37142
  • GENBANK/Z33259
  • SWISSPROT/L35044
  • SWISSPROT/S00015
  • SWISSPROT/S35616
  • SWISSPROT/S37140
  • SWISSPROT/S37142
  • SWISSPROT/Z33259