Pyridoxine dependent epilepsy with iatrogenic sensory neuronopathy

Can J Neurol Sci. 1995 Feb;22(1):50-1. doi: 10.1017/s0317167100040506.


An 18-year-old man was treated from birth with chronic high dose pyridoxine (vitamin B6) up to 2000 mg per day for pyridoxine-dependent seizures. Within two years of onset of treatment, he developed a sensory neuropathy which did not progress over the following 16 years. Electrophysiological studies were consistent with a pure sensory neuronopathy expressed as centripetal degeneration of processes of the dorsal root ganglion cells.

Publication types

  • Case Reports

MeSH terms

  • Action Potentials
  • Adolescent
  • Electrophysiology
  • Epilepsy / drug therapy*
  • Ganglia, Spinal
  • Humans
  • Iatrogenic Disease*
  • Male
  • Pyridoxine / adverse effects
  • Pyridoxine / pharmacology*
  • Seizures
  • Sensation Disorders*
  • Tibia


  • Pyridoxine