ATP Opens an Electrophoretic Potassium Transport Pathway in Respiring Yeast Mitochondria

FEBS Lett. 1995 May 8;364(2):161-4. doi: 10.1016/0014-5793(95)00380-r.

Abstract

In the presence of KCl and only at low phosphate concentrations, ATP stimulated state 4 of the respiration of isolated yeast mitochondria. This effect could be related to a partial collapse of the transmembrane potential which was created by the respiratory chain or the F0F1-ATPase. Sodium and lithium could not replace potassium ion. Atractyloside prevented the opening of this K+ pathway, suggesting that only matricial ATP operated. All these effects were inhibited by increasing phosphate concentration, or by adding propranolol, quinine, Zn2+ or Mg2+.

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Adenosine Triphosphate / pharmacology*
  • Energy Metabolism / drug effects
  • Ion Transport / drug effects
  • Magnesium / pharmacology
  • Membrane Potentials / drug effects
  • Mitochondria / drug effects*
  • Mitochondria / metabolism*
  • Oxygen Consumption / drug effects
  • Phosphates / pharmacology
  • Potassium / metabolism*
  • Potassium Chloride / pharmacology
  • Propranolol / pharmacology
  • Quinine / pharmacology
  • Saccharomyces cerevisiae / drug effects*
  • Saccharomyces cerevisiae / metabolism*
  • Zinc / pharmacology

Substances

  • Phosphates
  • Potassium Chloride
  • Adenosine Triphosphate
  • Propranolol
  • Quinine
  • Magnesium
  • Zinc
  • Potassium