Parallel computation of genetic likelihoods using CRI-MAP, PVM, and a network of distributed workstations

T C Matise; M D Schroeder; D M Chiarulli; D E Weeks

doi:10.1159/000154268

Parallel computation of genetic likelihoods using CRI-MAP, PVM, and a network of distributed workstations

Hum Hered. 1995 Mar-Apr;45(2):103-16. doi: 10.1159/000154268.

Authors

T C Matise¹, M D Schroeder, D M Chiarulli, D E Weeks

Affiliation

¹ Department of Human Genetics, University of Pittsburgh, Pa 15261, USA.

PMID: 7750973
DOI: 10.1159/000154268

Abstract

We have developed a version of the CRI-MAP computer program for genetic likelihood computations that runs the FLIPS and ALL functions of CRI-MAP in parallel on a distributed network of workstations. The performance of CRI-MAP-PVM was assessed in several linkage analyses using the FLIPS option of CRI-MAP on a map of 85 microsatellite markers for human chromosome 1. These analyses showed excellent speedup and efficiency and low distribution overhead. In addition, we have adapted the MultiMap program for automated construction of linkage maps to use CRI-MAP-PVM. These improvements significantly reduce the time required to compare likelihoods of different marker orders. Thus, the construction of linkage maps can proceed in a more timely fashion, in keeping with recent advances in genotyping technology.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Algorithms
Computer Communication Networks
Genetic Linkage*
Software*

Grants and funding

HG00932/HG/NHGRI NIH HHS/United States