Gastrointestinal absorption of pravastatin in healthy subjects

J Clin Pharmacol. 1995 Feb;35(2):142-4. doi: 10.1002/j.1552-4604.1995.tb05002.x.


The bioavailability of pravastatin, a hypocholesterolmic agent, may be enhanced by decreasing its exposure to stomach contents, where it may be converted nonenzymatically to a relatively inactive metabolite. The pharmacokinetics of pravastatin and its metabolite were determined after infusion of pravastatin directly into the stomach (locus for greatest bioavailability for the metabolite), duodenum (greatest bioavailability for pravastatin), jejunum, or ileum. An enterically coated formulation of pravastatin may increase its bioavailability.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Biological Availability
  • Drug Administration Schedule
  • Duodenum / metabolism
  • Gastric Mucosa / metabolism
  • Humans
  • Ileum / metabolism
  • Intestinal Absorption*
  • Intubation, Gastrointestinal
  • Jejunum / metabolism
  • Male
  • Pravastatin / administration & dosage
  • Pravastatin / pharmacokinetics*


  • Pravastatin