Evidence of increased intrauterine bone resorption in term infants of mothers with insulin-dependent diabetes

J Pediatr. 1995 May;126(5 Pt 1):796-8. doi: 10.1016/s0022-3476(95)70414-0.


Infants of diabetic mothers (IDMs) have lower bone mineral content than control subjects at birth. We measured cord blood propeptide of type I procollagen (PICP), a marker of bone formation, and telopeptide of type I collagen (ICTP), a marker of bone resorption, in 25 term IDMs and 20 term control subjects. Concentrations of ICTP were higher in IDMs than in control subjects; there was no difference in PICP concentrations. We conclude that osteoclastic activity appears to be higher in IDMs than in control subjects in utero.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Analysis of Variance
  • Biomarkers / blood
  • Birth Weight
  • Bone Density
  • Bone Resorption / blood*
  • Case-Control Studies
  • Collagen / analysis
  • Collagen Type I
  • Diabetes Mellitus, Type 1 / blood*
  • Female
  • Fetal Blood / metabolism
  • Fetal Diseases / blood*
  • Humans
  • Infant, Newborn
  • Peptide Fragments / blood
  • Peptides / analysis
  • Pregnancy
  • Pregnancy in Diabetics / blood*
  • Procollagen / blood
  • Prospective Studies


  • Biomarkers
  • Collagen Type I
  • Peptide Fragments
  • Peptides
  • Procollagen
  • collagen type I trimeric cross-linked peptide
  • procollagen type I carboxy terminal peptide
  • Collagen