Coenzyme Q10 in essential hypertension

Mol Aspects Med. 1994;15 Suppl:s257-63. doi: 10.1016/0098-2997(94)90036-1.

Abstract

This study was undertaken to clarify the mechanism of the antihypertensive effect of coenzyme Q10 (CoQ10). Twenty-six patients with essential arterial hypertension were treated with oral CoQ10, 50 mg twice daily for 10 weeks. Plasma CoQ10, serum total and high-density lipoprotein (HDL) cholesterol, and blood pressure were determined in all patients before and at the end of the 10-week period. At the end of the treatment, systolic blood pressure (SBP) decreased from 164.5 +/- 3.1 to 146.7 +/- 4.1 mmHg and diastolic blood pressure (DBP) decreased from 98.1 +/- 1.7 to 86.1 +/- 1.3 mmHg (P < 0.001). Plasma CoQ10 values increased from 0.64 +/- 0.1 microgram/ml to 1.61 +/- 0.3 micrograms/ml (P < 0.02). Serum total cholesterol decreased from 222.9 +/- 13 mg/dl to 213.3 +/- 12 mg/dl (P < 0.005) and serum HDL cholesterol increased from 41.1 +/- 1.5 mg/dl to 43.1 +/- 1.5 mg/dl (P < 0.01). In a first group of 10 patients serum sodium and potassium, plasma clinostatic and orthostatic renin activity, urinary aldosterone, 24-hour sodium and potassium were determined before and at the end of the 10-week period. In five of these patients peripheral resistances were evaluated with radionuclide angiocardiography. Total peripheral resistances were 2,283 +/- 88 dyne.s.cm-5 before treatment and 1,627 +/- 158 dyn.s.cm-5 after treatment (P < 0.02). Plasma renin activity, serum and urinary sodium and potassium, and urinary aldosterone did not change. In a second group of 11 patients, plasma endothelin, electrocardiogram, two-dimensional echocardiogram and 24-hour automatic blood pressure monitoring were determined.(ABSTRACT TRUNCATED AT 250 WORDS)

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Aldosterone / urine
  • Antihypertensive Agents / therapeutic use*
  • Blood Pressure / drug effects
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Coenzymes
  • Echocardiography
  • Electrocardiography
  • Endothelins / blood
  • Female
  • Humans
  • Hypercholesterolemia / complications
  • Hypercholesterolemia / drug therapy
  • Hypertension / blood
  • Hypertension / complications
  • Hypertension / drug therapy*
  • Male
  • Middle Aged
  • Potassium / metabolism
  • Renin / blood
  • Sodium / metabolism
  • Treatment Outcome
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / blood
  • Ubiquinone / therapeutic use
  • Vascular Resistance / drug effects

Substances

  • Antihypertensive Agents
  • Cholesterol, HDL
  • Coenzymes
  • Endothelins
  • Ubiquinone
  • Aldosterone
  • Cholesterol
  • Sodium
  • Renin
  • coenzyme Q10
  • Potassium