Abstract
Diffractaic acid and usnic acid were identified as the analgesic and antipyretic components of a lichen, Usnea diffracta. Both compounds showed an analgesic effect by the acetic acid-induced writhing and tail-pressure methods in mice. Regarding the effect on normal body temperature and LPS-induced hyperthermia in mice, diffractaic acid showed a significant effect only on the former and usnic acid only on the latter.
MeSH terms
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Analgesics / chemistry
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Analgesics / pharmacology*
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Analgesics, Non-Narcotic / chemistry
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Analgesics, Non-Narcotic / pharmacology*
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Anisoles / chemistry
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Anisoles / pharmacology*
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Benzofurans / chemistry
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Benzofurans / pharmacology*
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Chromatography, Thin Layer
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Hydroxybenzoates / chemistry
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Hydroxybenzoates / pharmacology*
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Magnetic Resonance Spectroscopy
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Plants, Medicinal / chemistry*
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Spectrophotometry, Infrared
Substances
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Analgesics
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Analgesics, Non-Narcotic
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Anisoles
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Benzofurans
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Hydroxybenzoates
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usnic acid
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diffractaic acid