Nonspecific interstitial pneumonia with fibrosis: radiographic and CT findings in seven patients

Radiology. 1995 Jun;195(3):645-8. doi: 10.1148/radiology.195.3.7753988.


Purpose: To describe the radiographic and computed tomographic (CT) findings in seven patients with nonspecific interstitial pneumonia with fibrosis (NIP).

Materials and methods: NIP was proved pathologically in all patients. Findings at radiography and initial and 1-15-month follow-up CT were reviewed.

Results: The predominant radiographic abnormalities were areas of patchy parenchymal opacification present bilaterally in the middle and lower lung zones in six patients; in one patient, the chest radiograph depicted no abnormality. The most common finding observed on initial thin-section CT scans was bilateral, patchy areas of ground-glass attenuation present alone or with areas of consolidation in five patients (71%) or irregular lines in two (29%). At follow-up CT, the initial parenchymal abnormalities had resolved completely in three patients, improved in another three, and persisted in one.

Conclusion: Bilateral patchy areas of opacity depicted radiographically and good clinical response to treatment may differentiate NIP from other interstitial pneumonias.

MeSH terms

  • Adult
  • Female
  • Humans
  • Lung / diagnostic imaging
  • Lung / pathology
  • Lung Diseases, Interstitial / diagnostic imaging*
  • Lung Diseases, Interstitial / pathology
  • Male
  • Middle Aged
  • Pulmonary Fibrosis / diagnostic imaging
  • Pulmonary Fibrosis / pathology
  • Tomography, X-Ray Computed*