Clinicopathologic correlation of an epiretinal membrane associated with a recurrent macular hole

Retina. 1995;15(1):53-7. doi: 10.1097/00006982-199515010-00010.


Purpose: To describe the clinicopathologic features of an epiretinal membrane associated with a recurrent, full-thickness idiopathic macular hole and speculate on the mechanism(s) contributing to its recurrence 1 year after initially successful closure of pars plana vitrectomy and gas tamponade (SF6).

Methods: After fixation of the 2 x 1 mm specimen in a mixture of 1% glutaraldehyde and 4% formaldehyde followed by 2.5% glutaraldehyde, postfixation with osmium tetroxide, and standard dehydration, the specimen was embedded in epoxy resin. Ultrathin sections were stained with uranyl acetate and lead citrate for transmission electron microscopy.

Results: Ultrastructural examination disclosed a fibrocellular membrane composed of Müller cells and fibrous astrocytes. Native collagen was entrapped in the matrix in some areas.

Conclusion: Those cells that may lead to the closure of an idiopathic macular hole may also contribute to its recurrence if the reparative process goes awry.

Publication types

  • Case Reports

MeSH terms

  • Cell Membrane / pathology
  • Cryosurgery
  • Female
  • Fibrosis
  • Fundus Oculi
  • Humans
  • Middle Aged
  • Recurrence
  • Retina / pathology*
  • Retinal Perforations / pathology*
  • Retinal Perforations / surgery
  • Sulfur Hexafluoride
  • Visual Acuity
  • Vitrectomy


  • Sulfur Hexafluoride