Objective: The authors examined the efficacy of methylphenidate in the treatment of depression in a group of older, medically ill patients.
Method: Sixteen patients underwent an 8-day double-blind, randomized, placebo-controlled crossover trial; 13 completed the trial.
Results: Statistically and clinically significant treatment responses were found.
Conclusions: These results support the use of methylphenidate in older, medically ill patients in whom rapid resolution of depressive symptoms is crucial.