Double-blind, placebo-controlled trial of methylphenidate in older, depressed, medically ill patients

Am J Psychiatry. 1995 Jun;152(6):929-31. doi: 10.1176/ajp.152.6.929.


Objective: The authors examined the efficacy of methylphenidate in the treatment of depression in a group of older, medically ill patients.

Method: Sixteen patients underwent an 8-day double-blind, randomized, placebo-controlled crossover trial; 13 completed the trial.

Results: Statistically and clinically significant treatment responses were found.

Conclusions: These results support the use of methylphenidate in older, medically ill patients in whom rapid resolution of depressive symptoms is crucial.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Comorbidity
  • Cross-Over Studies
  • Depressive Disorder / drug therapy*
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Methylphenidate / therapeutic use*
  • Placebos
  • Treatment Outcome


  • Placebos
  • Methylphenidate