A macrocircular ellagitannin, oenothein B, suppresses mouse mammary tumor gene expression via inhibition of poly(ADP-ribose) glycohydrolase

Biochem Biophys Res Commun. 1995 May 16;210(2):329-37. doi: 10.1006/bbrc.1995.1665.


Oenothein B, a macrocircular dimeric ellagitannin, was found to be a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase. Oenothein B suppressed glucocorticoid-sensitive mouse mammary tumor virus (MMTV) transcription in 34I cells. This suppression was accompanied by inhibition of glucocorticoid-induced endogeneous de-poly(ADP-ribosyl)ation of high mobility group (HMG) 14 and 17 proteins. These results suggest that de-poly(ADP-ribosyl)ation of these proteins may be closely connected with the events initiating glucocorticoid-sensitive MMTV gene transcription.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Gene Expression Regulation, Viral / drug effects*
  • Glycoside Hydrolases / antagonists & inhibitors*
  • High Mobility Group Proteins / metabolism
  • Hydrolyzable Tannins*
  • Mammary Tumor Virus, Mouse / drug effects*
  • Mammary Tumor Virus, Mouse / genetics
  • Mice
  • Mice, Inbred C3H
  • RNA, Messenger / genetics
  • Tannins / pharmacology*
  • Tumor Cells, Cultured


  • High Mobility Group Proteins
  • Hydrolyzable Tannins
  • RNA, Messenger
  • Tannins
  • oenothein B
  • Glycoside Hydrolases
  • poly ADP-ribose glycohydrolase