Microtubules and microtubule-associated proteins

Curr Opin Cell Biol. 1995 Feb;7(1):72-81. doi: 10.1016/0955-0674(95)80047-6.

Abstract

Microtubule research is becoming increasingly diverse, reflecting the many isoforms and modifications of tubulin and the many proteins with which microtubules interact. Recent advances are particularly visible in four areas: microtubule motor proteins (their structures, stepping modes, and forces); microtubule nucleation (the roles of centrosomes and gamma-tubulin); tubulin folding (mediated by cytoplasmic chaperones); and the expanding list of microtubule-associated proteins, knowledge of their phosphorylation states, and information on their effects on microtubule dynamics.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Movement / physiology
  • Centrosome / chemistry
  • Microtubule-Associated Proteins / chemistry*
  • Microtubules / ultrastructure*
  • Molecular Chaperones / chemistry
  • Sequence Homology, Nucleic Acid
  • Tubulin / chemistry
  • Tubulin / metabolism
  • tau Proteins / physiology

Substances

  • Microtubule-Associated Proteins
  • Molecular Chaperones
  • Tubulin
  • tau Proteins