Chronic tobacco smoking and gender as variables affecting amantadine disposition in healthy subjects

Br J Clin Pharmacol. 1995 Jan;39(1):81-4. doi: 10.1111/j.1365-2125.1995.tb04414.x.

Abstract

Amantadine HCl (3 mg kg-1) was administered orally to 20 young healthy adults. Its apparent volume of distribution (V2/F) was higher in smokers than nonsmokers, 6.05 +/- 0.86 vs 4.87 +/- 0.85 l kg-1; (mean +/- s.d., 10/group, P < 0.011), and no gender-associated effect was observed. Renal clearance did not vary with time-interval, but urinary recovery at 48 h was higher in men than in women (60.2 +/- 7.5% vs 47.0 +/- 15.0%, P < 0.032). Males had higher renal clearances than females when normalised for body mass index (BMI, 0.492 +/- 0.284 vs 0.248 +/- 0.137 l-1 BMI h-1, (10/group, P < 0.032)). On combining data from a previous study, the weight normalised renal clearance was also higher in men than in women, 0.160 +/- 0.075 vs 0.102 +/- 0.053 l kg-1 h-1 (19/group, P < 0.01). Chronic tobacco smoking did not alter the plasma or renal amantadine clearance. We conclude that gender and tobacco smoking are independent variables effecting amantadine disposition.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Amantadine / administration & dosage
  • Amantadine / blood
  • Amantadine / pharmacokinetics*
  • Amantadine / urine
  • Analysis of Variance
  • Body Mass Index
  • Chromatography, Gas
  • Confidence Intervals
  • Female
  • Humans
  • Kidney / metabolism
  • Male
  • Sex Characteristics*
  • Smoking / adverse effects
  • Smoking / metabolism*

Substances

  • Amantadine