Kainate receptors: a novel mechanism in paradoxical (REM) sleep generation

Neuroreport. 1995 Jan 26;6(2):353-6.

Abstract

Application of kainate to the peri-locus coeruleus alpha (peri-LC alpha) resulted in a marked increase in paradoxical sleep (PS). This effect was completely blocked by specific non-NMDA receptor antagonists, but not by selective NMDA receptor antagonists. Kainate was 10 times more potent than AMPA, and their site of action was confined to the peri-LC alpha. This study is the first to show that excitatory amino acids play an important role in PS generation via the activation of kainate receptors which are located in the peri-LC alpha of the mediodorsal pontine tegmentum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cats
  • Kainic Acid / antagonists & inhibitors
  • Kainic Acid / pharmacology*
  • Receptors, Kainic Acid / drug effects*
  • Receptors, Kainic Acid / physiology
  • Sleep, REM / drug effects*
  • Tegmentum Mesencephali / drug effects*

Substances

  • Receptors, Kainic Acid
  • Kainic Acid