Plasma fructosamine, total proteins and albumin were estimated in a group of 77 sickle cell anaemia and 32 glucose-6-phosphate dehydrogenase (G6PD)-deficient Saudi Arabs and the results compared with those obtained in a group of 30 normal controls. The mean values of fructosamine in the sickle cell anaemia and G6PD-deficient patients were not statistically different from those of the controls. The mean values of the total proteins and albumin were also not significantly different from those of the normal group. It is concluded that fructosamine level is not affected by sickle cell anaemia and G6PD deficiency, and provides a useful tool for monitoring diabetic patients in regions with high prevalence of haemoglobinopathies and G6PD deficiency.