[The cardioprotective and antiadrenergic activity of an extract of Rhodiola rosea in stress]

Eksp Klin Farmakol. 1994 Nov-Dec;57(6):61-3.
[Article in Russian]

Abstract

The course of administration of Rhodiola rosea extract was studied for effects on the pattern of stress-induced cardiac damage which was assessed by 99mTc-pyrophosphate accumulation in the heart. Rhodiola rosea was found to prevent stress-induced cardiac damage. Simultaneously, myocardial catecholamines and cAMP levels were measured. Rhodiola rosea was ascertained to prevent both stress-induced catecholamine release and higher cAMP levels in the myocardium. Moreover, the adaptogen prevented lower adrenal catecholamines during stress. The findings suggest that the antistressor and cardioprotective effects of Rhodiola rosea are associated with limited adrenergic effect on the heart.

Publication types

  • Comparative Study

MeSH terms

  • Adrenergic Antagonists / therapeutic use*
  • Animals
  • Cardiovascular Agents / therapeutic use*
  • Cold Temperature / adverse effects
  • Drug Evaluation, Preclinical
  • Heart / diagnostic imaging
  • Myocardium / metabolism
  • Plant Extracts / therapeutic use*
  • Radionuclide Imaging
  • Rats
  • Rats, Wistar
  • Stress, Psychological / diagnostic imaging
  • Stress, Psychological / drug therapy*
  • Stress, Psychological / etiology
  • Stress, Psychological / metabolism
  • Technetium Tc 99m Pyrophosphate

Substances

  • Adrenergic Antagonists
  • Cardiovascular Agents
  • Plant Extracts
  • Technetium Tc 99m Pyrophosphate