Modulation of the electrical differentiation of neurons by interactions with glia and other non-neuronal cells

Perspect Dev Neurobiol. 1995;2(4):357-70.

Abstract

Glial cells have long been recognized as participating in development of neural tissue by providing a scaffolding for migration and by synthesis and secretion of a variety of growth factors and extracellular matrix components. An additional role for glia and other non-neuronal cells in the electrical differentiation of neurons has been suggested by several recent articles, in particular a group that has focused on the potassium currents that influence action potential repolarization and repetitive activity. In this review I present examples of developmental regulation of potassium currents by interactions with non-neuronal cells and discuss some implications of this regulation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Communication*
  • Cell Differentiation
  • Chick Embryo
  • Chickens
  • Embryonic and Fetal Development
  • Hippocampus / physiology
  • Mice
  • Nervous System / cytology
  • Nervous System / embryology
  • Nervous System Physiological Phenomena*
  • Neuroglia / physiology*
  • Neurons / cytology
  • Neurons / physiology*
  • Parasympathetic Nervous System / physiology
  • Potassium Channels / biosynthesis
  • Potassium Channels / physiology*
  • Rats
  • Sympathetic Nervous System / physiology

Substances

  • Potassium Channels