Effect of gamma-hydroxybutyrate and its antagonist NCS-382 on spontaneous cell firing in the prefrontal cortex of the rat

Brain Res. 1995 Feb 27;673(1):157-60. doi: 10.1016/0006-8993(94)01461-p.


Gamma-hydroxybutyrate (GHB) at low doses (5-10 mg/kg i.p.) increased and at high doses (160-320 mg/kg i.p.) decreased the spontaneous firing rate of prefrontal cortex (PFC) neurons recorded in urethane-anesthetized rats. Only excitations were blocked by NCS-382, a specific GHB receptor antagonist; this suggests that the excitatory effect of low doses of GHB is mediated by a GHB receptor whereas the inhibitory effect of high doses of GHB involves a more complex mechanism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anticonvulsants / pharmacology*
  • Benzocycloheptenes / pharmacology*
  • Dose-Response Relationship, Drug
  • Electrophysiology
  • Male
  • Neural Conduction / drug effects*
  • Prefrontal Cortex / drug effects*
  • Prefrontal Cortex / physiology
  • Rats
  • Rats, Sprague-Dawley
  • Sodium Oxybate / pharmacology*
  • Time Factors


  • Anticonvulsants
  • Benzocycloheptenes
  • NCS 382
  • Sodium Oxybate