Mutation position and type of substitution in the beta-subunit of the RNA polymerase influence in-vitro activity of rifamycins in rifampicin-resistant Mycobacterium tuberculosis

J Antimicrob Chemother. 1995 Feb;35(2):345-8. doi: 10.1093/jac/35.2.345.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / pharmacology
  • DNA-Directed RNA Polymerases / genetics*
  • Drug Resistance, Microbial / genetics
  • Genes, Bacterial / drug effects
  • Genotype
  • Humans
  • Microbial Sensitivity Tests
  • Mutation*
  • Mycobacterium tuberculosis / drug effects*
  • Mycobacterium tuberculosis / enzymology
  • Mycobacterium tuberculosis / isolation & purification
  • Phenotype
  • Rifabutin / pharmacology*
  • Rifampin / analogs & derivatives*
  • Rifampin / pharmacology*
  • Tuberculosis, Pulmonary / microbiology

Substances

  • Antitubercular Agents
  • Rifabutin
  • DNA-Directed RNA Polymerases
  • Rifampin
  • rifapentine