cDNA cloning of mouse VLA-3 alpha subunit

J Cell Biochem. 1995 Feb;57(2):371-7. doi: 10.1002/jcb.240570221.


cDNA clones for mouse VLA (very late antigen)-3 alpha subunit (alpha 3 integrin) were isolated and sequenced. The encoded mouse alpha 3 integrin subunit was composed of 1,053 amino acid residues. The results of sequence analysis revealed similar structural characteristics of other VLA alpha subunits. For example, the presence of a large extracellular domain including three putative metal binding sequences, a transmembrane domain, and a short cytoplasmic domain. A higher level of its message was detected in thymus than in kidney, stomach, spleen, liver, brain, or lung by Northern blotting analysis.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3T3 Cells
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Line, Transformed
  • Cloning, Molecular
  • DNA, Complementary
  • Humans
  • Macromolecular Substances
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Protein Conformation
  • RNA, Messenger / metabolism
  • Receptors, Very Late Antigen / biosynthesis*
  • Receptors, Very Late Antigen / chemistry
  • Receptors, Very Late Antigen / genetics
  • Restriction Mapping
  • Sequence Homology, Amino Acid
  • Simian virus 40


  • DNA, Complementary
  • Macromolecular Substances
  • RNA, Messenger
  • Receptors, Very Late Antigen

Associated data

  • GENBANK/D13867