Abstract
By using a variety of molecular techniques, we have characterized the cytokine profile of pro-T cells. During this characterization we cloned a novel cytokine that has chemotactic activities. We have designated this cytokine lymphotactin. The structural analysis, chromosomal location, and biological properties of lymphotactin provide strong evidence that this cytokine represents a new class of chemokine.
MeSH terms
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Animals
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Cell Differentiation
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Chemokine CCL4
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Chemokines, C*
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Cloning, Molecular
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Cytokines / biosynthesis*
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Cytokines / physiology
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DNA, Complementary / genetics
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Gene Expression
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Lymphocyte Activation
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Lymphokines / physiology*
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Macrophage Inflammatory Proteins
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Mice
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Monokines / physiology
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Sialoglycoproteins / physiology*
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T-Lymphocytes / cytology
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T-Lymphocytes / metabolism*
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Thymus Gland / metabolism*
Substances
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Chemokine CCL4
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Chemokines, C
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Cytokines
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DNA, Complementary
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Lymphokines
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Macrophage Inflammatory Proteins
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Monokines
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Sialoglycoproteins
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Xcl1 protein, mouse
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lymphotactin