Receptors, signal transduction, and spectrum of action of monocyte chemotactic protein-1 and related chemokines

J Leukoc Biol. 1995 May;57(5):788-94. doi: 10.1002/jlb.57.5.788.


Chemokines are a bipartite family of chemotactic proteins that bear the structural hallmark of four cysteine residues, the first two of which are in tandem. The spectrum of action of C-C chemokines, monocyte chemotactic protein-1 (MCP-1), MCP-2, and MCP-3, in particular, encompasses, in addition to monocytes, other leukocyte populations. Evidence is presented that MCP-1, MCP-2, and MCP-3 are active on natural killer cells. Available information on receptor usage by MCP-1 and related chemokines and signal transduction pathways is reviewed. A better understanding of signaling mechanisms will provide a new basis for therapeutic strategies.

Publication types

  • Review

MeSH terms

  • Calcium / physiology
  • Chemokine CCL2
  • Chemotactic Factors / physiology*
  • Chemotaxis
  • Cytokines / physiology*
  • Humans
  • Monocytes / physiology
  • Receptors, Cytokine / physiology*
  • Recombinant Proteins
  • Signal Transduction*


  • Chemokine CCL2
  • Chemotactic Factors
  • Cytokines
  • Receptors, Cytokine
  • Recombinant Proteins
  • Calcium