Fibroblasts as efficient antigen-presenting cells in lymphoid organs

T M Kündig; M F Bachmann; C DiPaolo; J J Simard; M Battegay; H Lother; A Gessner; K Kühlcke; P S Ohashi; H Hengartner

doi:10.1126/science.7761853

Fibroblasts as efficient antigen-presenting cells in lymphoid organs

Science. 1995 Jun 2;268(5215):1343-7. doi: 10.1126/science.7761853.

Authors

T M Kündig¹, M F Bachmann, C DiPaolo, J J Simard, M Battegay, H Lother, A Gessner, K Kühlcke, P S Ohashi, H Hengartner, et al.

Affiliation

¹ Institute of Experimental Immunology, University of Zürich, Switzerland.

PMID: 7761853
DOI: 10.1126/science.7761853

Abstract

Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antigen-Presenting Cells / immunology*
Cytotoxicity, Immunologic
Fibroblasts / immunology*
Glycoproteins / immunology
Histocompatibility Antigens Class I / immunology
L Cells
Lymphocytic Choriomeningitis / immunology
Lymphocytic choriomeningitis virus / immunology*
Lymphoid Tissue / immunology*
Mice
Mice, Inbred C57BL
Neoplasms / immunology
T-Lymphocytes, Cytotoxic / immunology*
Transfection
Tumor Cells, Cultured
Viral Proteins / immunology*

Substances

Glycoproteins
Histocompatibility Antigens Class I
Viral Proteins