Evaluation of large-needle biopsy for the diagnosis of cancer

Acta Cytol. 1995 May-Jun;39(3):449-52.


The arguments for a choice between a large or fine needle in the diagnosis of tumors are still unclear. This paper reviews the advantages and disadvantages of large-needle biopsy and fine needle aspiration. Reports indicate that although the procedures have the same diagnostic efficacy, the risk of tumor seeding is far higher following large-needle biopsy. For this reason it should be avoided for the diagnosis of cancer. The risk of tumor seeding after fine needle aspiration may be reduced by performance through a cover of normal parenchyma, by maintaining suction during withdrawal of the needle and by examining samples for quality during the procedure.

Publication types

  • Review

MeSH terms

  • Abdominal Neoplasms / diagnosis
  • Biopsy, Needle / adverse effects
  • Biopsy, Needle / methods*
  • Carcinoma, Bronchogenic / diagnosis
  • Evaluation Studies as Topic
  • Humans
  • Lung Neoplasms / diagnosis
  • Male
  • Mesothelioma / diagnosis
  • Neoplasm Seeding
  • Neoplasms / diagnosis*
  • Pleural Neoplasms / diagnosis
  • Prostatic Neoplasms / diagnosis
  • Risk Factors