Tympanic membrane rupture following general anesthesia with nitrous oxide: a case report

AANA J. 1995 Feb;63(1):42-4.


Although rare, tympanic membrane rupture during general anesthesia with nitrous oxide has been reported previously in the literature. Nitrous oxide administration and the effects on closed body cavities will be reviewed. Key factors in patient assessment which can determine safe use of nitrous oxide in the clinical setting will also be discussed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Anesthesia, General / adverse effects*
  • Female
  • Humans
  • Nitrous Oxide / adverse effects*
  • Tympanic Membrane Perforation / chemically induced*


  • Nitrous Oxide