A nested case-control study on the association between Helicobacter pylori infection and gastric cancer risk in a cohort of 9775 men in Taiwan

Anticancer Res. 1995 Mar-Apr;15(2):603-6.


A nested case-control study was carried out to investigate the association between Helicobacter pylori infection and gastric cancer risk in Taiwan. A total of 29 patients newly affected with gastric cancer and 220 healthy controls matched with cases on age, sex and residence were selected from a cohort of 9,775 men recruited from 1984 through 1986. Frozen serum samples collected at recruitment examination were tested for IgG antibodies against Helicobacter pylori by an enzyme-linked immunosorbent assay. The average interval between serum collection and cancer diagnosis was 3.1 years. Gastric cancer cases had a higher seropositive prevalence (69%) than matched controls (59%) giving an odds ratio of 1.6 (95%) confidence interval = 0.7-2.6). Compared with previous nested case-control studies, Helicobacter pylori infection in early childhood may be a risk factor for gastric cancer. However, a long induction period seems required for gastro-carcinogenesis associated with Helicobacter pylori infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antibodies, Bacterial / blood
  • Case-Control Studies
  • Child
  • Cocarcinogenesis
  • Cohort Studies
  • Comorbidity
  • Gastritis / blood
  • Gastritis / epidemiology*
  • Helicobacter Infections / blood
  • Helicobacter Infections / epidemiology*
  • Helicobacter pylori* / immunology
  • Humans
  • Immunoglobulin G / blood
  • Male
  • Middle Aged
  • Odds Ratio
  • Prevalence
  • Risk
  • Seroepidemiologic Studies
  • Stomach Neoplasms / epidemiology*
  • Stomach Neoplasms / microbiology
  • Taiwan / epidemiology
  • Time Factors


  • Antibodies, Bacterial
  • Immunoglobulin G