Helicobacter pylori increases gene expression of hepatocyte growth factor in human gastric mucosa

Biochem Biophys Res Commun. 1995 May 25;210(3):960-5. doi: 10.1006/bbrc.1995.1750.


Helicobacter pylori (H. pylori) induces hyperproliferation of the gastric mucosa. This study was designed to clarify whether H. pylori infection is involved in the gene expression of hepatocyte growth factor (HGF), a potent stimulator of cell proliferation in gastric mucosa. Levels of HGF mRNA were determined by a reverse transcription-polymerase chain reaction in endoscopic gastric biopsy specimens from 9 control subjects and 9 patients with H. pylori infection. In patients with H. pylori infection, levels of HGF mRNA in gastric mucosa were significantly higher than those in control subjects. HGF mRNA levels in patients with H. pylori infection were correlated with the severity of gastric mucosal inflammation. Our observations indicate that H. pylori infection increases the expression of HGF gene in gastric mucosa probably through the mucosal inflammation.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Animals
  • Base Sequence
  • Chromatography, High Pressure Liquid
  • DNA / chemistry
  • DNA / isolation & purification
  • DNA Primers
  • Female
  • Gastric Mucosa / metabolism*
  • Gastric Mucosa / microbiology*
  • Gastric Mucosa / pathology
  • Gene Expression*
  • Helicobacter Infections / metabolism*
  • Helicobacter Infections / pathology
  • Helicobacter pylori / physiology*
  • Hepatocyte Growth Factor / biosynthesis*
  • Humans
  • Inflammation
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • RNA, Messenger / analysis
  • RNA, Messenger / biosynthesis
  • Rats
  • Reference Values


  • DNA Primers
  • RNA, Messenger
  • Hepatocyte Growth Factor
  • DNA