Abstract
Malformin B, produced by Aspergillus niger, was separated into six compounds by HPLC. Their structures were determined by amino acid analyses, and by mass spectral and two-dimensional NMR experiments to be cyclic pentapeptides structurally related to malformin A1. Both the NMR and MS/MS experiments suggest cyclo-D-cysteinyl-D-cysteinyl-L-amino acid-D-amino acid-L-amino acid as the essential structure of malformins.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Amino Acids / analysis
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Aspergillus niger / metabolism*
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Chromatography, High Pressure Liquid
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Sequence Data
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Molecular Structure
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Peptides, Cyclic / biosynthesis
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Peptides, Cyclic / chemistry*
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Peptides, Cyclic / isolation & purification
Substances
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Amino Acids
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Peptides, Cyclic
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malformins