Stimulation of nerve growth factor production by pyrroloquinoline quinone and its derivatives in vitro and in vivo

Biosci Biotechnol Biochem. 1993 Jul;57(7):1231-3. doi: 10.1271/bbb.57.1231.


Pyrroloquinoline quinone (PQQ), which is a cofactor of microbial quinoprotein enzymes, was found to be a potent enhancer of nerve growth factor (NGF) production in vitro. One of PQQ derivatives, oxazopyrroloquinoline trimethylester, had little activity in vitro, but increased the NGF content in rat brain in vivo.

MeSH terms

  • Animals
  • Brain / drug effects*
  • Brain / metabolism
  • Cell Line
  • Male
  • Nerve Growth Factors / biosynthesis*
  • Oxazoles / pharmacology*
  • PQQ Cofactor
  • Quinolines / pharmacology*
  • Quinolones / metabolism
  • Quinolones / pharmacology*
  • Rats
  • Rats, Wistar


  • Nerve Growth Factors
  • Oxazoles
  • Quinolines
  • Quinolones
  • oxazopyrroloquinoline trimethyl ester
  • PQQ Cofactor