Antimicrobial isoflavans from Astragalus species

Phytochemistry. 1994 Aug;36(6):1387-9. doi: 10.1016/s0031-9422(00)89728-9.

Abstract

Two new antimicrobial isoflavans, 1-[(3R)-7,8-dimethoxybenzopyranyl]-4- hydroxybenzoquinone (astragaluquinone) and (3S)-7,1'-dihydroxy-8,3'-dimethoxyisoflavan (8-methoxyvestitol), and the known 7-hydroxy-2',3',4'-trimethoxyisoflavan were isolated from roots of Astragalus alexandrinus and A. trigonus. The structures of the new isoflavans were established by spectroscopic methods.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anti-Bacterial Agents
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / pharmacology*
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology*
  • Benzopyrans / chemistry
  • Benzopyrans / pharmacology*
  • Benzoquinones
  • Candida albicans / drug effects
  • Carbohydrate Sequence
  • Isoflavones*
  • Klebsiella pneumoniae / drug effects
  • Magnetic Resonance Spectroscopy
  • Medicine, Chinese Traditional
  • Microbial Sensitivity Tests
  • Micrococcus luteus / drug effects
  • Molecular Sequence Data
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Quinones / chemistry
  • Quinones / pharmacology*
  • Saccharomyces cerevisiae / drug effects
  • Staphylococcus aureus / drug effects

Substances

  • 8-methoxyvestitol
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antifungal Agents
  • Benzopyrans
  • Benzoquinones
  • Isoflavones
  • Quinones
  • astragaluquinone