Abstract
Two new antimicrobial isoflavans, 1-[(3R)-7,8-dimethoxybenzopyranyl]-4- hydroxybenzoquinone (astragaluquinone) and (3S)-7,1'-dihydroxy-8,3'-dimethoxyisoflavan (8-methoxyvestitol), and the known 7-hydroxy-2',3',4'-trimethoxyisoflavan were isolated from roots of Astragalus alexandrinus and A. trigonus. The structures of the new isoflavans were established by spectroscopic methods.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anti-Bacterial Agents
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / pharmacology*
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology*
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Benzopyrans / chemistry
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Benzopyrans / pharmacology*
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Benzoquinones
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Candida albicans / drug effects
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Carbohydrate Sequence
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Isoflavones*
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Klebsiella pneumoniae / drug effects
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Magnetic Resonance Spectroscopy
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Medicine, Chinese Traditional
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Microbial Sensitivity Tests
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Micrococcus luteus / drug effects
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Molecular Sequence Data
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Quinones / chemistry
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Quinones / pharmacology*
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Saccharomyces cerevisiae / drug effects
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Staphylococcus aureus / drug effects
Substances
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8-methoxyvestitol
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Anti-Bacterial Agents
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Anti-Infective Agents
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Antifungal Agents
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Benzopyrans
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Benzoquinones
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Isoflavones
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Quinones
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astragaluquinone