Adenosine release in the ventral striatum of the rat is modulated by endogenous nitric oxide

Eur J Pharmacol. 1995 Mar 14;275(3):R5-6. doi: 10.1016/0014-2999(95)00097-5.


The influence of nitric oxide (NO) on adenosine release was investigated by the push-pull technique in the ventral striatum of the urethane-anaesthetized rat. Superfusion with the NO donor diethylamine-NO enhanced, whereas superfusion with the NO synthase inhibitor L-NG-nitroarginine methyl ester decreased the output of adenosine. The effect of L-NG-nitroarginine methyl ester was abolished by L-arginine methyl ester. These findings indicate that, in the ventral striatum of the rat, NO modulates adenosine release.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine / metabolism*
  • Animals
  • Arginine / analogs & derivatives
  • Arginine / pharmacology
  • Corpus Striatum / metabolism*
  • Male
  • Nitric Oxide / physiology*
  • Nitroarginine
  • Rats
  • Rats, Sprague-Dawley


  • Nitroarginine
  • Nitric Oxide
  • Arginine
  • Adenosine