Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification

FASEB J. 1995 May;9(8):576-96.


The eukaryotic protein kinases make up a large superfamily of homologous proteins. They are related by virtue of their kinase domains (also known as catalytic domains), which consist of approximately 250-300 amino acid residues. The kinase domains that define this group of enzymes contain 12 conserved subdomains that fold into a common catalytic core structure, as revealed by the 3-dimensional structures of several protein-serine kinases. There are two main subdivisions within the superfamily: the protein-serine/threonine kinases and the protein-tyrosine kinases. A classification scheme can be founded on a kinase domain phylogeny, which reveals families of enzymes that have related substrate specificities and modes of regulation.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Binding Sites
  • Catalysis
  • Eukaryotic Cells / enzymology*
  • Forecasting
  • Humans
  • Molecular Sequence Data
  • Protein Conformation
  • Protein Kinases / chemistry*
  • Protein Kinases / classification*
  • Sequence Homology, Amino Acid


  • Protein Kinases