Treatment of hyperhidrosis with topical methenamine

Int J Dermatol. 1976 Jul-Aug;15(6):452-5. doi: 10.1111/j.1365-4362.1976.tb00240.x.


Idiopathic palmar and plantar hyperhidrosis is a relatively common disorder of eccrine sweat gland function. Treatment with glutaraldehyde of formaldehyde, although successful, may cause undesirable side effects. Methenamine is a polycyclic organic compound which release ammonia and formaldehyde at acid pH. Five per cent methenamine in a firm stick gel, applied daily to one palmar or plantar surface of 109 patients with hyperhidrosis, resulted in significantly less sweating after one month. No patients were sensitized to formaldehyde.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Chemical Phenomena
  • Chemistry
  • Clinical Trials as Topic
  • Drug Evaluation
  • Humans
  • Hyperhidrosis / drug therapy*
  • Methenamine / therapeutic use*


  • Methenamine