Appropriate response to pneumococcal vaccine in celiac sprue

J Clin Gastroenterol. 1995 Mar;20(2):113-6. doi: 10.1097/00004836-199503000-00008.


Hyposplenism as a complication of celiac sprue confers an increased risk of pneumococcal sepsis, but such patients do not routinely receive pneumococcal vaccine despite reports of overwhelming pneumococcal sepsis. Because antibody response in these patients has not been previously assessed, we measured pre- and postvaccination levels in 10 patients with documented sprue. All demonstrated appropriate acute antibody responses to a polyvalent pneumococcal vaccine. Vaccination of all patients with celiac sprue seems appropriate.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Antibodies, Bacterial / immunology
  • Antibody Formation / immunology
  • Bacterial Vaccines*
  • Celiac Disease / complications*
  • Celiac Disease / immunology*
  • Female
  • Humans
  • Pneumococcal Infections / prevention & control*
  • Pneumococcal Vaccines
  • Splenic Diseases / etiology*
  • Splenic Diseases / immunology
  • Streptococcus pneumoniae / immunology
  • Vaccination*


  • Antibodies, Bacterial
  • Bacterial Vaccines
  • Pneumococcal Vaccines