[Changes in the sensitivity of leukocytes to the inhibiting effect of CO2 on their generation of active forms of oxygen in bronchial asthma patients]

Ter Arkh. 1995;67(3):23-6.
[Article in Russian]


30 bronchial asthma (BA) patients and 15 donors were exposed to 8.3% and 20.8% CO2 to bring out leukocytes sensitivity to CO2 by generation of active oxygen (AO) in bronchial asthma. CO2 effects on leukocyte AO generation were defined by luminol-dependent chemiluminescence (CL) before and after the exposure to CO2. It was found that in healthy subjects 8.3% and 20.8% CO2 noticeably inhibits leukocyte CL. However, in 70% of asthmatics with BA exacerbation leukocyte sensitivity to CO2 inhibition diminished. This was normal in 30% of BA patients. With BA aggravation, leukocyte sensitivity to CO2 tended to a decrease. Remission brought a complete or partial recovery of the above sensitivity. Thus, on the one hand, CO2 is involved in BA pathogenesis in terms of its inhibitory effect on AO generation by leukocytes; on the other hand, only in 30% of BA patients high CO2 concentrations as a treatment may be justified.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Asthma / blood*
  • Blood Donors
  • Carbon Dioxide / pharmacology*
  • Depression, Chemical
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Leukocytes / drug effects*
  • Leukocytes / metabolism
  • Luminescent Measurements
  • Luminol / pharmacology
  • Male
  • Middle Aged
  • Oxygen / blood*


  • Carbon Dioxide
  • Luminol
  • Oxygen